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Pipeline Comparison

Pipeline Comparison: Company vs Company

Compare pipelines on PoS-weighted forward NPV.

A structured way to compare pharma pipelines company-by-company — phase, modality, TA distribution and PoS-weighted forward NPV.

Decision angle

"Whose pipeline is structurally stronger — by what measure, in what TA?"

TL;DR

Asset-count comparisons mislead. PoS-weighted forward NPV across TA and modality reveals real strength differential.

Pipeline comparison decoupled from PoS-weighted NPV is theatre. Done right, it’s the most actionable BD and IC input strategy can produce.

Key insights

What we’re seeing in the data.

01

Count ≠ value

50 P1s ≠ 5 P3s in NPV.

02

Concentration matters

TA-concentrated outperform diffuse.

03

Modality breadth signals platform

Vs opportunistic dealmaking.

PoS-w
Always weight
Realistic
NPV
Output
Forward
TA × phase × mod
Slice
Cross
Live
Refresh
Continuous
Decision framework

How to think about it.

  1. 01

    Build pipeline universe

    All credible candidates per company.

  2. 02

    Score per asset

    PoS, launch, peak revenue.

  3. 03

    Aggregate by TA

    Forward NPV.

  4. 04

    Compare across companies

    Slice by modality, phase, geo.

Considerations

What separates a good answer from a defensible one.

Manufacturing capacity

Limits realized launches.

Combination dependencies

Link asset NPVs.

IP windowing

Shapes effective revenue arc.

Sources & tools

Where the signal comes from.

Citeline Cortellis EvaluatePharma forecasts Internal NPV models
FAQ

Common questions.

Why not analyst forecasts?

Often outdated within a quarter.

Granularity for BD?

Asset-level with explicit assumptions.

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We build decision systems on top of analyses like this — so the next question takes minutes, not weeks.

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